Oxymatrine

Sophora flavescens is a plant of Sophora flavescens. Located in the north and South provinces of Russia, Japan, India, North Korea and China, the area grows at 1500 meters above sea level.

The Root Extract contains a variety of alkaloids with medicinal effects. The main components are D-matrine, Doxymatrine, and a small amount of D-sophoranole and

Lanagyrine. Root Extract has a strong anti-inflammatory and anti allergic effect, can reduce the release of allergic media, is an excellent immunosuppressant, and has a very good relieving effect on skin itching symptoms.

Physicochemical Properties

English Name	Comfort Matrine
INCI Name	Root Extract
CAS No.	519-02-8
Feature	White powder with slight characteristic odour
Content	＞99.0%（HPLC）
Solubility	Soluble in water, benzene, chloroform and ethanol

The Efficacy of Oxymatrine

√ quickly inhibit skin itching and relieve skin over stimulation

√ strong anti allergy and anti inflammation, enhance skin cell immunity

√ stabilize the cell membrane and inhibit the release of inflammatory mediators

√ natural alkaloids, mild and non irritating

1. Relieve itching

Pruritus is caused by the stimulation of the free nerve endings network at the junction of epidermis and dermis. It is connected with the brain through the afferent and efferent nerve reflexes. Various kinds of stimulation can induce the feeling of pruritus.

The basic unit between the stimulation of pruritus and the impulses of free nerve endings is a medium with physiological activity. Histamine is the material basis of pruritus. It is a kind of chemical transfer medium in organism. It exists in basophils and cytoplasmic granules of mast cells in human body. There is a positive correlation between skin allergy, inflammation and pruritus and the release of histamine in mast cells. Any factor that causes the stimulation of mast cells can make mast cells release histamine from degranulation, thus causing the release of histamine itch. Therefore, antihistamines and stable mast cells can be used to reduce histamine release in clinic, which can treat the common itching phenomenon. As a common concomitant disease of skin sensitivity, itching has the similar main allergen and action way with allergic reaction. Experiments show that inhibiting the occurrence of type I hypersensitivity can reduce the incidence of itching to a large extent.

Oxymatrine has a strong inhibitory effect on histamine release, 0.5% of the dosage can effectively inhibit 87.4% of histamine release, and can reduce skin sensitivity and discomfort caused by histamine and seasonal replacement.

In the experiment, mast cell degranulation (compound 48 / 80) was used to induce the release of histamine from guinea pig mast cells in vitro. Histamine release from guinea pig mast cells was determined by HPLC.

The results showed that Oxymatrine at 0.1% had a good inhibition effect on histamine release, and could inhibit 56.9% histamine release. At 0.5% dosage, the histamine inhibition rate of comfort SGS was 87.4%. In allergy treatment, histamine released by mast cells and basophils can be blocked from the source to attack and sensitize the target organs, so as to achieve the effect of relieving skin itching.

Histamine release inhibition rate

Blank group

Experimental group 1

Experimental group 2

2. Regulate cellular skin immune activity

Comfort Matrine is a bi-directional immunomodulator, which can stimulate the proliferation of lymphocytes at low concentration and promote the ability of skin cells to resist the adverse environment. When the concentration is high, it can produce immunosuppressive effect, that is, it can regulate the release of inflammatory mediators in cells, and avoid the cells in an over excited state, so as to produce allergic and other inflammatory symptoms.

3. Inhibition of Hyaluronidase release

Hyaluronidase is a participant in anaphylaxis, because it can decompose Hyaluronic Acid in the enzyme, make it become a low molecular weight acid stimulus, induce the body to produce stimulation and other sensitive symptoms. Matrine has a strong inhibitory effect on Hyaluronidase activity, so as to prevent further damage to skin cells and play a good protective role.

Product Application

Application description and safety

Recommended dosage: 0.1-0.5%

usage method:

① Emulsification system: add deionized water, dissolve evenly, and add to the system at about 50 ℃

Gel system: directly added to the system at about 50 degrees Celsius, stirring and dissolving evenly.

Use product:

◆ anti allergy care

◆ anti itching care

◆ whitening products

◆ baby care

Safety: no irritation, no toxicity and no side effects to eyes and skin; biodegradable

Stability: no discoloration, no peculiar smell and no deactivation within the shelf life

Application Example

Fuhreb Herbal Medicine Sophorae Flavescens Acne Mask

Relieve acne, improve water and oil imbalance skin, control oil and moisture, improve acne, inhibit oil

RADIX SOPHORAE FLAVESCENTIS ANTI-ACNE CREAM

Sophorae flavescens and aloe are two core plant punishment ingredients, which can effectively dissolve pox roots, relieve skin discomfort, balance oil secretion, deeply supplement water and control oil, and deeply repair pox muscles.

Sophoare combine with Gentian, Golden cypress, honeysuckle and other herbaceous extracts. Highly effective, comfortable and bacteriostatic, mildly calm baby's skin, enhance skin resistance.