Oxymatrine can inhibit the proliferation of endothelial cells induced by lung cancer and gastric cancer cells.
Oxymatrine has the effect of anti hepatitis B virus, can reduce the content of HBsAg and HBcAg in the liver of HBV transgenic mice, and has the same effect on both, no selective effect. Oxymatrine is a strong immunosuppressant, can inhibit the release of a variety of inflammatory factors, has a clear anti-inflammatory effect, and can induce Lak by IL-2 Therefore, it is unlikely that Oxymatrine can exert its anti HBV effect through cytokines such as IL-2.
The western use of Sophora Sophora: its original plant and hot water extract have been used for 25 years in the West. The Sophora alopecuroides alkaloid extract, which initially contains 20% Oxymatrine and matrine, was introduced into the western market by the window Research Institute in the form of tablet under the name Oxymatrine, which was listed in 1998. Its use has no side effects. In China, Sophora flavescens alkaloids are usually injected, but this method is not accepted in the west, but oral form. After oral administration, most of oxymatrine is converted into matrine; if the high blood concentration of oxymatrine is needed, injection must be relied on. However, it is not known whether the curative effect of oxymatrine is better than that of matrine in clinical trials. Chinese researchers also use matrine in tablets, which seems to work as well as injections.
There are a lot of alkaloids in Sophora flavescens, the highest of which are matrine and Oxymatrine, which account for 2% of the total dry weight of Sophora flavescens (most of them are in the form of oxymatrine), and there are other similar alkaloids: sophocarpine (c15h22n2o), sophoraol, Sophoramine, Sophoridine, isomatrine and other alkaloids. These components were first found in Sophora flavescens from 1958 to 1978.